Thermo Fisher Scientific Human PKR Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the amino terminus of human PKR.
PEP-0418 can be used as a blocking peptide with polyclonal antibody PA5-20284.

Target Information

EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses.
EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection. PKR is involved in IFN-induced innate antiviral response, virus-induced apoptosis, cell growth, and differentiation.

PKR induces apoptosis by up-regulating Fas expression and mediates the FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival and cell death pathways using kinase-independent and kinase-dependent strategies.

PRKR regulates multiple pathways including NF-kappaB activation, p53, p38, and PDGF signaling. PKR has been implicated in tumor suppression and malignancy. Viruses have evolved mechanisms to inhibit PKR, such as through the non-structural protein (NS1) of the influenza virus.

More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis (ALS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.