Thermo Fisher Scientific beta-2 Microglobulin Recombinant Superclonal Antibody (4HCLC)

Applications

• Western Blot (WB): 0.5–2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with non-human primate, mouse, and rat based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.

While functionally similar to polyclonal antibodies—recognizing multiple epitopes and providing higher sensitivity for low-abundance targets—Superclonal™ antibodies have a precisely defined mixture of light and heavy chains, ensuring consistent production across lots.

Note: Formerly called “Recombinant Polyclonal Antibody,” now rebranded as “Recombinant Superclonal™ Antibody.” The physical product and performance remain unchanged.

Target Information

Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the MHC class I complex. It is expressed on various cell types, including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes.

B2M is also found in free form in plasma and shares homology with immunoglobulin constant regions. It plays roles in antigen presentation, TCR signaling, and CD8+ T cell activation. The B2M gene is located on chromosome 15, and mutations can cause hypercatabolic hypoproteinemia.

Beta-2 microglobulin levels can serve as a renal function biomarker and prognostic marker for HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.