Thermo Fisher Scientific ERBB3 Monoclonal Antibody (OTI3C1), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors that binds to ligands in the heregulin family.
It is over-expressed in various tumors including prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on chromosome 12q13 and encodes a 160/180 kDa transmembrane glycoprotein receptor tyrosine kinase.
ErbB3 forms heterodimers with other EGF receptor family members, activating pathways leading to cell proliferation or differentiation.
Alternate splice variants include a secreted isoform lacking the transmembrane region, which modulates the activity of the membrane-bound form.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.