Thermo Fisher Scientific CD49c (Integrin alpha 3) Monoclonal Antibody (7H2A11)
인간 CD49c(Integrin alpha 3)를 인식하는 Mouse IgG1 단클론 항체로, WB, Flow Cytometry, ELISA에 적합합니다. 단백질 G로 정제된 액상 형태이며, PBS 버퍼와 0.05% sodium azide를 포함합니다. 연구용으로만 사용 가능합니다.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7H2A11 |
| Immunogen | Purified recombinant fragment of human CD49c (AA: extra 63–248) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090824 |
Target Information
ITGA3 (Integrin alpha-3), also known as CD49c, VLA3, or GAPB3, is encoded by the ITGA3 gene in humans. It is an integrin alpha subunit and a member of the cell surface adhesion molecule family.
ITGA3 is located on chromosome 17q21.33 and forms the alpha3beta1 integrin duplex, which plays a role in neural migration and corticogenesis alongside the beta-1 subunit.
A functional link between DAB1 phosphorylation and ITGA3 signaling regulates the detachment of migrating neurons from radial glial fibers.
Expression of human ITGA3 increases viral infectivity in Chinese hamster ovary cells.
ITGA3 contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and 7 N-terminal repeating units typical of integrins.
Recombinant ITGA3 is expressed as a 150-kDa protein, matching the native protein size in Western blot analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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