Thermo Fisher Scientific CD137 Monoclonal Antibody (4G10B9)
인간 CD137(4-1BB)을 인식하는 Mouse IgG1 단클론 항체입니다. Western blot, Flow cytometry, ELISA 등 다양한 응용에 최적화되어 있습니다. 단백질 G 정제, PBS 버퍼 및 sodium azide 포함. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific CD137 Monoclonal Antibody (4G10B9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G10B9 |
| Immunogen | Purified recombinant fragment of human CD137 (AA: extra 24–186) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090780 |
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and clonal expansion of activated and memory T cells, while modulating myelopoiesis and dendritic cell development. Triggered CD137 induces cytokine release regulating monocyte survival. Soluble CD137 may act as a negative regulator in immune responses.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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