Thermo Fisher Scientific CHRNA4 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHRNA4 (AAH96292.1, 1 a.a. approximately 451 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CHRNA4,uniProtId:P43681-1,ncbiNodeId:9606,antigenRange:1-627,antigenLength:627,antigenImageFileName:H00001137-B01P_CHRNA4_P43681-1_House_mouse.svg,antigenImageFileNamePDP:H00001137-B01P_CHRNA4_P43681-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MKFGSWTYDK AKIDLVNMHS RVDQLDFWES GEWVIVDAVG TYNTRKYECC AEIYPDITYA FVIRRLPLFY TINLIIPCLL ISCLTVLVFY LPSECGEKIT LCISVLLSLT VFLLLITEII PSTSLVIPLI GEYLLFTMIF VTLSIVITVF VLNVHHRSPR THTMPTWVRR VFLDIVPRLL LMKRPSVVKD NCRRLIESMH KMASAPRFWP EPEGEPPATS GTQSLHPPSP SFCVPLDVPA EPGPSCKSPS DQLPPQQPLE AEKASPHPSP GPCRPPHGTQ APGLAKARSL SVQHMSSPGE AVEGGVRCRS RSIQYCVPRD DAAPEADGQA AGALASRNTH SAELPPPDQP SPCKCTCKKE PSSVSPSATV KTRSTKAPPP HLPLSPALTR AVEGVQYIAD HLKAEDTDFS VKEDWKYVAM VIDRIFLWMF IIVCLLGTVG LFLPPWLAGM I

Target Information

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.