Thermo Fisher Scientific CHRNA4 Monoclonal Antibody (4E3)
CHRNA4 단백질을 인식하는 Mouse monoclonal antibody(클론 4E3). Western blot과 ELISA에 적합하며, 인간 시료 반응성 확인. PBS 기반 무보존제 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E3 |
| Immunogen | CHRNA4 (NP_000735, 29 a.a. ~128 a.a.) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
HVETRAHAEE RLLKKLFSGY NKWSRPVANI SDVVLVRFGL SIAQLIDVDE KNQMMTTNVW VKQEWHDYKL RWDPADYENV TSIRIPSELI WRPDIVLYNN
Target Information
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, causing conformational changes that open an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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