Thermo Fisher Scientific Alpha A Crystallin Recombinant Rabbit Monoclonal Antibody (ARC1245)
Alpha A Crystallin 단백질을 인식하는 재조합 토끼 모노클로날 항체로, Western blot, ICC/IF, ELISA에 적합합니다. HEK293 세포에서 발현되며, 높은 특이성과 재현성을 제공합니다. 연구용으로 사용되며, 렌즈 단백질 구조 및 기능 연구에 이상적입니다.
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Thermo Fisher Scientific Alpha A Crystallin Recombinant Rabbit Monoclonal Antibody (ARC1245)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1245 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 6–95 of human CRYAA (P02489) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849546 |
Product Specific Information
Immunogen sequence:
QHPWFKRTLG PFYPSRLFDQ FFGEGLFEYD LLPFLSSTIS PYYRQSLFRT VLDSGISEVR SDRDKFVIFL DVKHFSPEDL TVKVQDDFVE
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest and composed of two primary gene products—alpha-A and alpha-B.
Alpha-Crystallin comprises 40% of total lens protein composition and functions as a chaperone to prevent aggregate formation that may lead to cataract development.
Phosphorylated states of alpha-crystallin respond to cellular stress and may play a role in protein maintenance. Alpha-B crystallin accumulation has been linked to Alexander’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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