Thermo Fisher Scientific ATP1B1 Recombinant Rabbit Monoclonal Antibody (ARC1232)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
YNPNVLPVQC TGKRDEDKDK VGNVEYFGLG NSPGFPLQYY PYYGKLLQPK YLQPLLAVQF TNLTMDTEIR IECKAYGENI GYSEKDRFQG RFDVKIEVKS

Target Information

The protein encoded by this gene belongs to the family of Na⁺/K⁺ and H⁺/K⁺ ATPase beta chain proteins, and to the subfamily of Na⁺/K⁺-ATPases.
Na⁺/K⁺-ATPase is an integral membrane protein responsible for maintaining electrochemical gradients of Na⁺ and K⁺ ions across the plasma membrane. These gradients are essential for osmoregulation, sodium-coupled transport of various molecules, and electrical excitability of nerve and muscle cells.
The enzyme consists of two subunits: a large catalytic alpha subunit and a smaller glycoprotein beta subunit. The beta subunit regulates the number of sodium pumps transported to the plasma membrane by forming alpha/beta heterodimers. The glycoprotein subunit is encoded by multiple genes, and this gene encodes the beta 1 subunit. Alternative splicing variants have been described, though their biological validity remains uncertain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.