Thermo Fisher Scientific CARD14 Polyclonal Antibody
CARD14 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western Blot, IHC, ELISA에 사용 가능하며, 고순도 Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며 연구용으로 적합합니다.
- 카탈로그번호
- PA5120462
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CARD14 Polyclonal Antibody
Thermo Fisher Scientific CARD14 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 200–500 of human CARD14 (NP_001244899.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.12 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914034 |
Product Specific Information
Positive test controls include HT-29 and HeLa cells.
The target is typically localized in the cytoplasm.
Immunogen sequence:
SLSLHYSNAL QEKELAASRC RSLQEELYLL KQELQRANMV SSCELELQEQ SLRTASDQES GDEELNRLKE ENEKLRSLTF SLAEKDILEQ SLDEARGSRQ ELVERIHSLR ERAVAAERQR EQYWEEKEQT LLQFQKSKMA CQLYREKVNA LQAQVCELQK ERDQAYSARD SAQREISQSL VEKDSLRRQV FELTDQVCEL RTQLRQLQAE PPGVLKQEAR TREPCPREKQ RLVRMHAICP RDDSDCSLVS STESQLLSDL SATSSRELVD SFRSSSPAPP SQQSLYKRVA EDFGEEPWSF S
Target Information
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and act as molecular scaffolds for multi-protein complexes.
The MAGUK family includes mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, tight junction proteins (ZO-1–3), and CARD proteins (CARD 6, 8–12, 14).
CARD14 is a 1,004 amino acid protein with:
- N-terminal CARD domain
- Central coiled-coil domain
- C-terminal tripartite domain (PDZ, SH3, and GUK domains)
CARD14 is expressed in the placenta, where it positively regulates apoptosis and controls NF-κB activation by phosphorylating BCL10.
Epigallocatechin-3-gallate (EGCG), a polyphenol, induces CARD14 expression.
Safety Information
⚠ WARNING: This product contains chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information: www.P65Warnings.ca.gov
Usage Restriction
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.