Thermo Fisher Scientific Progesterone Receptor Antibody Cocktail
Progesterone 수용체 검출용 Mouse IgG 항체 칵테일로, WB, IHC, ICC, IP 등 다양한 응용에 적합합니다. 인간 및 여러 동물 종에서 반응하며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Progesterone Receptor Antibody Cocktail
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | 15 |
| Immunohistochemistry (IHC) | - | 34 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25–1:50 | 1 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:25–1:50 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | 7 |
| ELISA | - | 1 |
| Immunoprecipitation (IP) | 2 µg/mL | - |
| ChIP assay (ChIP) | 2 µL/10^6 cells | 2 |
| Gel Shift (GS) | - | 1 |
| Miscellaneous PubMed (Misc) | - | 1 |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Bovine, Cat, Chicken, Deer, Horse, Human, Mouse, Rhesus monkey, Sheep |
| Host / Isotype | Mouse / IgG |
| Class | Cocktail |
| Type | Antibody |
| Clone | hPRa2, hPRa3 |
| Immunogen | Human endometrial carcinoma from in athymic mice |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1086828 |
Product Specific Information
MA1-12626 detects Progesterone Receptor in human, equine, and porcine samples.
It has been successfully used in immunofluorescence, immunoprecipitation, western blot, and immunohistochemistry (paraffin, frozen) procedures.
The immunogen is human endometrial carcinoma from in athymic mice.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with pregnancy.
PR exists as a 94 kDa protein (Form A) or a 120 kDa protein (Form B), resulting from alternative translation initiation sites. PR-B is transcriptionally active and regulates genes for endometrium maintenance, pregnancy, and ovulation inhibition.
PR-A differs from PR-B by a 165 amino acid deletion at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE), activating transcription.
Mutations in the PGR gene can lead to reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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