Thermo Fisher Scientific SMC1 Monoclonal Antibody (C2M)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Immunocytochemistry (ICC/IF)

5-10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

C2M

Immunogen

Recombinant protein corresponding to aa 402-894 of human SMC1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SMC1,uniProtId:Q14683-1,ncbiNodeId:9606,antigenRange:402-894,antigenLength:1233,antigenImageFileName:MA1-12604_SMC1_Q14683-1_House_mouse.svg,antigenImageFileNamePDP:MA1-12604_SMC1_Q14683-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:SMC1,uniProtId:Q8NDV3-3,ncbiNodeId:9606,antigenRange:402-894,antigenLength:1235,antigenImageFileName:MA1-12604_SMC1_Q8NDV3-3_House_mouse.svg,antigenImageFileNamePDP:MA1-12604_SMC1_Q8NDV3-3_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS

Contains

0.08% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1087352

Product Specific Information

A suggested positive control for this product is HeLa cells.

Target Information

Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.