Thermo Fisher Scientific TRAF5 Polyclonal Antibody
TRAF5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 사용 가능. Gerbil, Human, Mouse, Rat에 반응하며, whole serum 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-Dependent | |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-Dependent | |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Gerbil, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 1–20 of mouse TRAF5 (GenBank no. AAH12702.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718772 |
Target Information
Tumor necrosis factor (TNF)-induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins such as TNF receptor-associated factors (TRAFs).
TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF receptor superfamily (e.g., RANK, CD30, CD40) and the interleukin-1 receptor.
The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization.
Six TRAFs (TRAF1–TRAF6) have been identified. TRAF5 is a 558-amino acid protein implicated in NF-κB and c-Jun N-terminal kinase/stress-activated protein kinase activation by TNF receptor superfamily members including CD27, CD30, CD40, and lymphotoxin-beta receptor.
Targeted disruption of the TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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