Thermo Fisher Scientific VEGF Receptor 2 Polyclonal Antibody
VEGF Receptor 2를 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 조직에 반응하며 IHC(P)에서 10 µg/mL로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from internal region of human VEGFR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550354 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey (100%); Gibbon, Marmoset (94%); Mouse, Dog, Hamster, Elephant, Pig (88%); Rat, Bovine, Panda, Horse, Opossum, Turkey (81%). - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
- After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase that binds vascular endothelial growth factor (VEGF) with high affinity in vitro. It is expressed early in development by endothelial cell precursors.
FLK1 (VEGF Receptor 2) encodes one of the two receptors of VEGF, known as kinase insert domain receptor. Its signaling and trafficking are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin αVβ3, and T-cell protein tyrosine phosphatase.
Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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