Thermo Fisher Scientific P-Glycoprotein Chimeric Recombinant Rabbit Monoclonal Antibody (MRK16)
P-glycoprotein을 인식하는 키메라형 재조합 토끼 단클론 항체. ICC/IF, Flow Cytometry, IP에 사용 가능. 인간 시료 반응성. Protein A로 정제된 액상 항체로 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MRK16 |
| Immunogen | Drug resistant K-562 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074245 |
Product Specific Information
Specificity: Recognizes a discontinuous extracellular epitope on P-glycoprotein.
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily and is involved in multidrug resistance. The encoded protein functions as an ATP-dependent drug efflux pump with broad substrate specificity, reducing drug accumulation in multidrug-resistant cells and mediating resistance to anticancer drugs. It also acts as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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