Thermo Fisher Scientific Phospho-TrkB (Tyr817) Recombinant Rabbit Monoclonal Antibody (SC0556)

Thermo Fisher Scientific Phospho-TrkB (Tyr817) Recombinant Rabbit Monoclonal Antibody (SC0556)

Applications and Tested Dilution

• Western Blot (WB): 1:1,000–1:5,000
• Immunohistochemistry (Paraffin) [IHC (P)]: 1:1,000
• Immunocytochemistry (ICC/IF): 1:50–1:200

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to rabbit immune repertoire

Target Information

NTRK2 (TRKB) encodes a receptor for brain-derived neurotrophic factor (BDNF), playing a crucial role in development and maintenance of the mammalian nervous system.

• Regulates short-term synaptic functions and long-term potentiation.
• TrkB is a tyrosine kinase receptor expressed in central and peripheral nervous tissues.
• BDNF and NT-3 induce tyrosine phosphorylation of TrkB; BDNF response is significantly stronger.
• TrkB activation triggers MAPK pathway signaling, leading to cell differentiation.
• Mutations are linked to obesity and mood disorders.
• Multiple splice variants exist for TrkB.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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