Thermo Fisher Scientific Dectin 2 Polyclonal Antibody
Rabbit polyclonal antibody against human Dectin-2. Validated for WB and IHC. Lyophilized form for stable storage. Suitable for research on innate and adaptive immune signaling pathways. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human Dectin-2 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10999803 |
Product Specific Information
Reconstitute with 100 µL of distilled water before use.
Target Information
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain. Dectin-2 recognizes high mannose structures and mediates cytokine production from dendritic and other antigen-presenting cells.
Although Dectin-2 lacks obvious signaling motifs, it associates with FcRγ to activate the NF-κB pathway and cytokine production. Despite sharing only 20–25% sequence homology with Dectin-1, Dectin-2 functions as a pattern recognition receptor (PRR) for fungal infections, activating both innate (via Syk–CARD9 pathway) and adaptive immune responses. Thus, Dectin-2 serves as a connector molecule between innate and adaptive immunity at the dendritic cell level.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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