Thermo Fisher Scientific Dectin 2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute with 100 µL of distilled water before use.

Target Information

Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain. Dectin-2 recognizes high mannose structures and mediates cytokine production from dendritic and other antigen-presenting cells.
Although Dectin-2 lacks obvious signaling motifs, it associates with FcRγ to activate the NF-κB pathway and cytokine production. Despite sharing only 20–25% sequence homology with Dectin-1, Dectin-2 functions as a pattern recognition receptor (PRR) for fungal infections, activating both innate (via Syk–CARD9 pathway) and adaptive immune responses. Thus, Dectin-2 serves as a connector molecule between innate and adaptive immunity at the dendritic cell level.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.