Thermo Fisher Scientific CLAC-P Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

Immunohistochemistry (IHC)

1:100-1:200

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide: D(430) Y N G N L H E A L Q R I T(443) of the NC3 region of human and murine CLAC-P if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLAC-P,uniProtId:Q9BXS0-1,ncbiNodeId:9606,antigenRange:430-443,antigenLength:654,antigenImageFileName:PA1-4308_CLAC-P_Q9BXS0-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4308_CLAC-P_Q9BXS0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2276411

Product Specific Information

PA1-4308 detects CLAC-P (NC3 region) in human and mouse samples.

PA1-4308 has been successfully used in Western blotting and immunohistochemistry procedures. By Western blot, this antibody detects a ~70 kDa protein representing CLAC-P (NC3 region) in stable HEK293T cell lines expressing CLAC-P (NC3 region). PA1-4308 does not cross react with COLXIII or COLXXIII proteins.

PA1-4308 immunizing peptide corresponds to amino acid residues 430-443 of the NC3 region of human and mouse CLAC-P.

Maintain at 4ºC for 3 months or at -20ºC for longer periods. Avoid freeze/thaw cycles.

Target Information

Alzheimer`s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.