Thermo Fisher Scientific KCNMA1 Polyclonal Antibody
Rabbit polyclonal antibody targeting KCNMA1, validated for WB, IHC, ICC/IF, and IP. Lyophilized form with 0.6 mg/mL concentration, stored at -20°C. Specific for Maxi K+ channel studies in vascular and excitable cells.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:200 | |
| Immunohistochemistry (IHC) | Assay-Dependent | |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | GST fusion protein corresponding to residues 1097–1196 of mouse KCa 1.1 variant 2 (sequence: SHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQNATRMTRMGQAEKKWFTDEPDNAYPRNIQIKPMSTHMANQINQYKSTSSLIPPIREVEDEC) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.6 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736008 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
Potassium channels are ubiquitously expressed proteins serving numerous functions in excitable and non-excitable cells.
The large conductance, calcium-activated potassium channel (Maxi K+) is activated by both intracellular calcium increase and membrane depolarization.
Its structure includes a voltage sensor and intracellular calcium-binding domain.
In vascular smooth muscle, a beta-subunit is found in a 1:1 stoichiometry, decreasing the calcium concentration required to open the pore by 5–10 fold.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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