Thermo Fisher Scientific CRP Chimeric Recombinant Rabbit Monoclonal Antibody (P24)

Thermo Fisher Scientific CRP Chimeric Recombinant Rabbit Monoclonal Antibody (P24)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody reacts with human C-reactive protein (CRP), a pentameric protein found in blood plasma and produced by the liver as an acute phase reactant. Its plasma concentration increases sharply during tissue damage, inflammation, and bacterial infection. CRP promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through calcium-dependent binding to phosphorylcholine. It can also interact with DNA and histones, scavenging nuclear material released from damaged cells.

Target Information

CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein composed of five identical, noncovalently bound, nonglycosylated subunits. Each subunit consists of 206 amino acids with a molecular weight of 24 kDa. CRP is produced by the liver and its plasma levels rise dramatically during inflammation. It initiates the classical complement cascade, binds to nuclear components (chromatin, histones, etc.), and plays a key role in innate immunity and nonspecific host defense. CRP levels can increase 100–1000 fold in response to injury, infection, or inflammation. Elevated basal levels of CRP are associated with increased risk of hypertension and cardiovascular disease.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.