Thermo Fisher Scientific c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)
Thermo Fisher Scientific의 c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)은 인간 c-Myc 단백질을 인식하는 재조합 단클론 항체입니다. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합하며, 고순도 Protein A 정제 및 안정적 액상 형태로 제공됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)
Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | Synthetic peptide corresponding to aa 408–439 from C-terminus of human c-myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
Product Specific Information
Epitope sequence: EQKLISEEDL, located in aa 410–419 of human c-myc protein.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and cycle regulation.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression induces apoptosis in different cell types.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to amino- or carboxy-termini of target proteins.
Amplification of the c-Myc gene occurs in several human tumors, including lung, breast, and colon carcinomas, while N-Myc amplification is found in neuroblastomas.
Chromosomal translocations involving c-Myc are described in Burkitt’s lymphoma and other B-cell lymphoproliferative conditions.
Aberrant expression of c-Myc is observed in tumors of diverse origins such as colorectal, gastric, hepatic, ovarian, pulmonary, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.