Thermo Fisher Scientific c-Myc Oncoprotein Recombinant Rabbit Monoclonal Antibody (MYC/7682R)

Applications

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with regulation of proliferation and cell cycle.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression can induce apoptosis in different cell types.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags at either amino- or carboxy-termini.
Amplification of the c-Myc gene has been reported in various human tumors including lung, breast, and colon carcinomas, while N-Myc amplification occurs in neuroblastomas.
Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci (chromosomes 14, 2, or 22) is characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders.
Aberrant c-Myc expression is observed in tumors of colorectal, gastric, hepatic, mammary, ovarian, pulmonary, prostatic, thyroidal, and hematopoietic origins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.