Thermo Fisher Scientific c-Myc Oncoprotein Recombinant Rabbit Monoclonal Antibody (MYC/7854R)
Recombinant rabbit monoclonal antibody for c-Myc detection. Validated for WB and IHC applications. High specificity to human MYC protein fragment (aa1-200). Supplied as liquid, unconjugated form, 200 µg/mL concentration. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MYC/7854R |
| Immunogen | Recombinant fragment (around aa1–200) of human MYC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation of c-Myc at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK has been associated with cell proliferation and regulation.
Studies indicate that c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini of targeted proteins.
Amplification of the c-Myc gene has been found in several human tumors, including lung, breast, and colon carcinomas. Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is described in Burkitt’s lymphoma and other B-cell lymphoproliferative conditions. Aberrant expression of c-Myc occurs in tumors of various origins such as colorectal, gastric, hepatic, mammary, ovarian, and endocrine neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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