Thermo Fisher Scientific c-Myc Oncoprotein Recombinant Rabbit Monoclonal Antibody (MYC/7855R)

Applications and Tested Dilutions

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays key roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK has been linked to regulation of cell proliferation and cycle control. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular growth and differentiation, while deregulated expression induces apoptosis in certain cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tags at either the N- or C-terminus.

Amplification of the c-Myc gene is found in several human tumors including lung, breast, and colon carcinomas. N-Myc amplification is observed in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is associated with Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-myc expression occurs in tumors of various origins such as colorectal, gastric, hepatic, mammary, ovarian, endometrial, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.