Thermo Fisher Scientific c-Myc Oncoprotein Recombinant Rabbit Monoclonal Antibody (MYC/7683R)

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with regulation of cell proliferation and cycle control. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-Myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in various cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini of target proteins.

c-Myc, N-Myc, and L-Myc proteins function in cell proliferation, differentiation, and neoplastic disease. Amplification of the c-Myc gene is observed in lung, breast, and colon carcinomas, while N-Myc amplification is found in neuroblastomas. Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-Myc expression occurs in tumors of colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic origin, among others.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.