Thermo Fisher Scientific Phospho-MPRIP (Thr542) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MPRIP(Accession Q6WCQ1), corresponding to amino acid residues around phosphorylated Thr542. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MPRIP,uniProtId:Q6WCQ1-1,ncbiNodeId:9606,antigenRange:542,antigenLength:1025,antigenImageFileName:PA5-105059_MPRIP_Q6WCQ1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-105059_MPRIP_Q6WCQ1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2816532

Product Specific Information

Antibody detects endogenous levels of MRIP only when phosphorylated at Thr542.

Target Information

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.