Thermo Fisher Scientific Phospho-Occludin (Ser507 ) Polyclonal Antibody
Occludin 단백질의 Ser507 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 사용 가능. Human, Mouse, Rat 반응성. PBS buffer(50% glycerol) 보존, -20°C 보관. 연구용 전용 시약.
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- PA5105057
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC(P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from mouse OCLN (Accession Q16625), corresponding to amino acid residues around phosphorylated Ser507. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816530 |
Product Specific Information
This antibody detects endogenous levels of Occludin only when phosphorylated at Ser507 (mouse).
Target Information
Occludin is a 65 kDa protein that exists in various phosphorylated forms up to approximately 82 kDa. It plays a key role in regulating tight junction localization and function. Polyunsaturated fatty acids up-regulate occludin expression, enhancing transendothelial resistance and reducing permeability to large molecules. Expression levels vary by tissue: high and continuous in brain cell junctions, lower and discontinuous in non-neural tissues. Structural features are highly conserved across species. Under-expression of occludin and other tight junction proteins contributes to increased permeability in tumor endothelium, leading to brain tumor edema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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