Thermo Fisher Scientific NGF Recombinant Rabbit Monoclonal Antibody (R711)
Recombinant rabbit monoclonal antibody specific for human NGF/NGFB. Offers high specificity, sensitivity, and lot-to-lot consistency. Preservative-free formulation suitable for neutralization assays. Ideal for research on neuronal growth and differenti...
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Applications
Neutralization (Neu)
- Tested Dilution: 0.048–0.19 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | R711 |
| Immunogen | Recombinant Human NGF/NGFB Protein (Ser122–Arg239) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | Histidine/arginine, pH 6, with 120 mM NaCl, 0.02% Tween 80 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785305 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Human NGF/NGFB.
Target Information
Nerve Growth Factor (NGF) regulates survival and differentiation of neuronal and nonneuronal cells by binding to high- and low-affinity cell surface receptors. Only the high-affinity receptor mediates signal transduction.
Studies show the high-affinity receptor of rat PC12 cells forms a 158 kDa complex with NGF, while the low-affinity receptor forms a 100 kDa complex. Human and rat NGF receptor genes share over 90% sequence homology.
NGF promotes nerve growth and differentiation of sympathetic and sensory neurons, and its gene mutations are linked to hereditary sensory and autonomic neuropathy type 5 (HSAN5). Dysregulation of NGF expression is also associated with allergic rhinitis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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