ELK Biotechnology DJ-1 rabbit pAb
DJ-1 rabbit pAb는 인간 PARK7 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 산화 스트레스 관련 연구 및 파킨슨병 모델에서 유용하며, 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
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제품명
DJ-1 rabbit pAb
대체 명칭
PARK7; Protein DJ-1; Oncogene DJ1; Parkinson disease protein 7
적용 분야
- Western Blot (WB)
- Immunohistochemistry (IHC)
- Immunofluorescence (IF)
- ELISA
권장 희석 배율
- Western Blot: 1/500 – 1/2000
- Immunohistochemistry: 1/100 – 1/300
- ELISA: 1/20000
- 기타 응용은 아직 테스트되지 않음
면역원
Synthesized peptide derived from human PARK7 (AA range: 61–110)
일반 정보
| 항목 | 내용 |
|---|---|
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kD |
| Gene ID (Human) | 11315 |
| Human Swiss-Prot No | Q99497 |
| Species Reactivity | Human, Mouse, Rat |
세포 내 위치
Cell membrane, Lipid-anchor, Cytoplasm, Nucleus, Membrane raft, Mitochondrion, Endoplasmic reticulum.
Under normal conditions, predominantly located in the cytoplasm, and to a lesser extent in the nucleus and mitochondrion.
Translocates to mitochondrion and nucleus in response to oxidative stress, providing cytoprotective effects.
Detected in tau inclusions in brains from neurodegenerative disease patients.
Membrane raft localization in astrocytes and neuronal cells requires palmitoylation.
배경 정보
The product of this gene belongs to the peptidase C56 family. It acts as a positive regulator of androgen receptor-dependent transcription and may function as a redox-sensitive chaperone and oxidative stress sensor.
Protects neurons against oxidative stress and cell death.
Defects in this gene cause autosomal recessive early-onset Parkinson disease 7.
Two transcript variants encoding the same protein have been identified (RefSeq, Jul 2008).
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