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ELK Biotechnology DHRS4 rabbit pAb
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DHRS4 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 합성 펩타이드(AA 191-240)로 면역화. 인간, 생쥐, 랫트 반응성. 고순도 IgG, 1 mg/ml 농도. -20°C 보관으로 1년 안정.
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ELK Biotechnology ES2170-100UL DHRS4 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES2170-50UL DHRS4 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology DHRS4 rabbit pAb
제품명
DHRS4 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DHRS4; Dehydrogenase/reductase SDR family member 4; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human DHRS4 (AA range: 191–240) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 32–34 kDa |
| Gene ID (Human) | 10901 |
| Human Swiss-Prot No. | Q9BTZ2 |
| Cellular Localization | Isoform 1: Peroxisome Isoform 4: Not peroxisomal Isoform 7: Nucleus |
| Species Reactivity | Human; Rat; Mouse |
Background
- Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH
- Function: Reduces all-trans-retinal and 9-cis retinal; can catalyze oxidation of all-trans-retinol with NADP as cofactor (lower efficiency).
- Substrate specificity: Reduces alkyl phenyl ketones and α-dicarbonyl compounds with aromatic rings such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione, and 4-hexanoylpyridine.
- Inhibition: Inhibited by kaempferol, quercetin, genistein, and myristic acid.
- Similarity: Member of the short-chain dehydrogenases/reductases (SDR) family.
- Subunit: Homotetramer.
- Tissue specificity: Isoform 1 predominantly expressed in normal cervix (protein level). Isoform 4 expressed in some neoplastic cervical tissues, not in normal cervix. Isoforms 5 and 6 expressed in few neoplastic cervical tissues.
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