ELK Biotechnology DAN rabbit pAb
DAN 단백질에 특이적인 토끼 폴리클로날 항체로, 인간 NBL1 유래 펩타이드로부터 제작됨. WB, IHC, IF, ELISA에 사용 가능하며 다양한 종(Human, Rat, Mouse)에 반응. BMP 억제 단백질 연구 및 발달 생물학 연구에 적합.
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- ES2141-xxxxx (2개 옵션)
- 판매단위
- pk
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제품명
DAN rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NBL1; DAN; DAND1; Neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; Protein N03; Zinc finger protein DAN |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human NBL1 (AA range: 131-180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 19 kD |
| Gene ID (Human) | 4681 |
| Human Swiss-Prot No. | P41271 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]
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