ELK Biotechnology Bcl-w rabbit pAb
Bcl-w 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, 세포사멸 조절 연구에 유용합니다. 합성 펩타이드 유래 면역원으로 제작되었습니다.
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Bcl-w rabbit pAb
제품 개요
Bcl-w rabbit pAb는 인간 BCLW 단백질을 인식하는 토끼 폴리클로날 항체입니다. 세포사멸(apoptosis) 관련 단백질 연구에 사용되며, Western blot, Immunohistochemistry, Immunofluorescence, ELISA 등 다양한 응용에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Bcl-w rabbit pAb |
| Alternative Names | BCL2L2; BCLW; KIAA0271; Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human BCLW (AA range: 131–180) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kDa |
| Gene ID (Human) | 599 |
| Human Swiss-Prot No | Q92843 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Mitochondrion membrane; Peripheral membrane protein. Loosely associated with the mitochondrial membrane in healthy cells; tightly bound during apoptosis. |
Background
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
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