ELK Biotechnology BCSC-1 rabbit pAb
BCSC-1 단백질을 인식하는 rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 핵 및 핵질에 주로 위치합니다. 종양 억제 관련 연구 및 유전자 발현 분석에 유용한 고품질 항체입니다.
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제품명
BCSC-1 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | VWA5A; BCSC1; LOH11CR2A; von Willebrand factor A domain-containing protein 5A; Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A protein |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LHR2A (AA range: 371–420) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 86 kD |
| Gene ID (Human) | 4013 |
| Human Swiss-Prot No | O00534 |
| Cellular Localization | Nucleus, nucleoplasm |
| Species Reactivity | Human; Rat; Mouse |
Background
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A, is a 786 amino acid protein containing one VIT domain and one VWFA domain.
VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. It likely acts as a tumor suppressor gene — deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors and may serve as a potential gene therapy target.
Abnormal expression of VWA5A may increase adhesion of CNE-2L2 cells, associated with elevated E-cadherin, alpha-catenin, and p53 expression, resulting in reduced malignant activity in cells with ectopic VWA5A expression.
Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2.
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