ELK Biotechnology Dab1 rabbit pAb
Dab1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IF, ELISA에 사용 가능. 인간 Dab1 유래 합성 펩타이드로 면역화됨. 뉴런 발달 연구 및 신호전달 경로 분석에 적합. -20°C에서 1년 보관 가능.
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제품명
Dab1 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
Dab1 단백질에 특이적으로 결합하는 토끼 유래 폴리클로날 항체입니다. 뇌 발달 및 뉴런 위치 조절 연구에 활용되며, WB, IF, ELISA 등 다양한 분석에 적합합니다.
스펙 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DAB1; Disabled homolog 1 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Dab1 (AA range: 199–248) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 1600 |
| Human Swiss-Prot No | O75553 |
| Cellular Localization | nucleolus, microtubule organizing center, cytosol, brush border, postsynaptic density, membrane, neuron projection, neuronal cell body, intracellular membrane-bounded organelle, apical part of cell, perinuclear region of cytoplasm |
| Species Reactivity | Human; Mouse; Rat |
Background
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full-length nature has not been determined. (provided by RefSeq, Jul 2008)
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