ELK Biotechnology Cystatin A rabbit pAb
Cystatin A 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 세포질에 위치하며, 각질세포 발달 및 암 진단 연구에 활용 가능. -20°C에서 1년 보관.
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Cystatin A rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cystatin A rabbit pAb |
| Alternative Names | CSTA; STF1; STFA; Cystatin-A; Cystatin-AS; Stefin-A |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human Stefin A (AA range: 49–98) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 11 kDa |
| Gene ID (Human) | 1475 |
| Human Swiss-Prot No. | P01040 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Rat; Mouse |
Background
The cystatin superfamily encompasses proteins containing multiple cystatin-like sequences. Some members act as active cysteine protease inhibitors, while others have lost or never acquired this activity. The superfamily includes three inhibitory families: type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin functioning as a cysteine protease inhibitor, forming tight complexes with papain and cathepsins B, H, and L. It is a precursor protein of the cornified cell envelope in keratinocytes, playing a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. (RefSeq, Jul 2008)
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