ELK Biotechnology CYB5R3 rabbit pAb
CYB5R3 rabbit pAb는 인간 CYB5R3 단백질을 표적으로 하는 고품질 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며, 다양한 종(Human, Rat, Mouse)에 반응합니다. 고농도(1 mg/ml)로 제공되어 안정적인 신호 검출이 가능합니다.
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ELK Biotechnology CYB5R3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CYB5R3 rabbit pAb |
| Alternative Names | CYB5R3; DIA1; NADH-cytochrome b5 reductase 3; B5R; Cytochrome b5 reductase; Diaphorase-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CYB5R3 (AA range: 137-186) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| GeneID (Human) | 1727 |
| Human Swiss-Prot No | P00387 |
| Cellular Localization | Isoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side. Isoform 2: Cytoplasm. Produces the soluble form found in erythrocytes. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes.
The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism.
The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction.
The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain.
Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.
[provided by RefSeq, Jan 2010]
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