ELK Biotechnology c-Myc rabbit pAb
c-Myc 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포주기 조절 및 종양 관련 연구에 활용되며, 인간 MYC 유래 펩타이드로부터 제작되었습니다. 핵 및 인(nucleolus) 내에서 발현되는 단백질 검출에 유용합니다.
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ELK Biotechnology c-Myc rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | c-Myc rabbit pAb |
| Alternative Names | MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MYC. AA range: 386-435 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kDa (also ~60 kDa in some samples) |
| GeneID (Human) | 4609 |
| Human Swiss-Prot No | P01106 |
| Cellular Localization | Nucleus, nucleoplasm, nucleolus |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a multifunctional nuclear phosphoprotein involved in cell cycle progression, apoptosis, and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement, and translocation of this gene have been associated with various hematopoietic tumors, leukemias, and lymphomas, including Burkitt lymphoma. Evidence suggests that alternative translation initiations from upstream non-AUG (CUG) and downstream AUG start sites produce two isoforms with distinct N-termini. The non-AUG initiated protein synthesis is suppressed in Burkitt’s lymphomas, indicating its importance in normal gene function. [provided by RefSeq, Jul 2008]
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