ELK Biotechnology CLK2 rabbit pAb
CLK2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 CLK2 유래 펩타이드로 면역화. 핵 내에서 SR 단백질 인산화 조절 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
CLK2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CLK2; Dual specificity protein kinase CLK2; CDC-like kinase 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CLK2 (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kDa |
| GeneID (Human) | 1196 |
| Human Swiss-Prot No. | P49760 |
| Cellular Localization | Nucleus; Isoform 1: Nucleus, Nucleus speckle; Isoform 2: Nucleus speckle. Co-localizes with serine- and arginine-rich (SR) proteins in nuclear speckles. Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. |
| Species Reactivity | Human; Mouse; Rat |
Background
CDC-like kinase 2 (CLK2) is a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. It regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, influencing alternative transcript splicing. Chromosomal translocations between CLK2 and PAFAH1B3 genes on chromosome 19 can produce a fusion protein. CLK2 is distinct from TELO2 (GeneID: 9894), which also shares the CLK2 alias but functions in telomere length regulation. A pseudogene exists on chromosome 7. Alternative splicing results in multiple transcript variants. [RefSeq, Jun 2014]
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