Thermo Fisher Scientific LRP6 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LRP6, suitable for Western blot. Recognizes amino acids 20–325 of LRP6. Supplied as liquid, unconjugated form at 2.08 mg/mL. For research use only.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500 – 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–325 of human LRP6 (NP_002327.2). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.08 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913777 |
Product Specific Information
Positive test controls include: 293T, U-87MG.
The target is usually found in the following locations: endoplasmic reticulum, membrane, single-pass type I membrane protein.
Target Information
LRP6 is essential for the Wnt/beta-catenin signaling pathway, likely acting as a coreceptor together with Frizzled for Wnt.
It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3.
The interaction with DKK1 blocks LRP6-mediated Wnt/beta-catenin signaling via Kremen protein-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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