Thermo Fisher Scientific LRP6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500 - 1:2,000

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-325 of human LRP6 (NP_002327.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LRP6,uniProtId:O75581-1,ncbiNodeId:9606,antigenRange:20-325,antigenLength:1613,antigenImageFileName:PA5-120205_LRP6_O75581-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120205_LRP6_O75581-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.08 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2913777

Product Specific Information

Positive test controls include: 293T, U-87MG. The target is usually found in the following locations: Endoplasmic reticulum, Membrane, Single-pass type I membrane protein.

Target Information

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.