Thermo Fisher Scientific Phospho-SHP-1 (Ser534) Polyclonal Antibody
SHP-1 단백질의 Ser534 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, Rat, Human, Mouse 시료에 반응합니다. PBS/glycerol buffer로 안정화되어 -20°C에서 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PTPN6 (Accession P29350), corresponding to amino acid residues around phosphorylated Ser534 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816983 |
Product Specific Information
Antibody detects endogenous levels of SHP-1 only when phosphorylated at Ser534.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It contains two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, SHP-1 binds to tyrosine-phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase and suppression of Ros-dependent cell proliferation. In myeloid cells, SHP-1 associates with IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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