Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Monoclonal Antibody (SATB2/7110)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2 µg/mL

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold-associated regions. It recognizes the sugar-phosphate structure of double-stranded DNA and functions as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) and inducing chromatin-loop remodeling. SATB2 recruits chromatin remodeling enzymes such as HDACs and HATs to promoters and enhancers. It is essential for the initiation of upper-layer neuron-specific genetic programs and the repression of deep-layer neuronal genes, likely through modulation of BCL11B expression. SATB2 acts as a repressor of Ctip2 and plays a critical role in corticocortical connections in the developing cerebral cortex. Mutations in SATB2 are associated with cleft palate isolated (CPI).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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