Thermo Fisher Scientific ARNT Monoclonal Antibody (OTI1A1), TrueMAB
ARNT 단백질을 인식하는 Mouse monoclonal antibody로, Western blot, IHC, ICC/IF, Flow Cytometry에 적합합니다. Human 시료 반응성이 있으며, Lyophilized 형태로 제공됩니다. 고순도 Affinity chromatography 정제 및 PBS buffer, trehalose 함유.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A1 |
| Immunogen | Full length human recombinant protein of human ARNT produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
HIF-1 beta (ARNT) is a nuclear protein involved in mammalian oxygen homeostasis. It forms a heterodimer with HIF-1 alpha, regulating transcriptional responses to hypoxia.
Under normoxic conditions, HIF-1 alpha is hydroxylated and degraded, while HIF-1 beta remains stable.
Dysfunction of HIF-1 beta is associated with hypoxia-related diseases and renal cell carcinoma.
HIF-1 beta contributes to the pathophysiology of myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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