Thermo Fisher Scientific ARNT Monoclonal Antibody (OTI1D1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

HIF-1 beta, also known as ARNT (aryl hydrocarbon receptor nuclear translocator), is a nuclear protein involved in mammalian oxygen homeostasis. It forms a heterodimer with HIF-1 alpha, regulating cellular responses to hypoxia.
Under normoxic conditions, HIF-1 alpha is hydroxylated and degraded, while HIF-1 beta remains stable.
Dysfunction of HIF-1 beta has been associated with hypoxia-related diseases, renal cell carcinoma, and other pathological conditions such as myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.