Thermo Fisher Scientific Phospho-SRPK2 (Thr492) Polyclonal Antibody
SRPK2 단백질의 Thr492 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC(P), ICC/IF에 사용 가능. 인간 및 마우스 시료에 반응하며, 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SRPK2 around the phosphorylation site of Thr492. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899282 |
Product Specific Information
This antibody detects endogenous levels of SRPK2 only when phosphorylated at Thr492.
Target Information
SRPK2, along with SRPK1, is likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection, representing an important host target for therapeutic intervention. It promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression through phosphorylation of SRSF2, which suppresses p53/TP53 phosphorylation. This relieves p53/TP53’s repression of cyclin-D1 expression. SRPK2 also phosphorylates ACIN1, redistributing it from nuclear speckles to the nucleoplasm, resulting in up-regulation of cyclin A1 but not A2. It plays an essential role in spliceosomal B complex formation via phosphorylation of DDX23/PRP28 and negatively regulates HBV replication by reducing pregenomic RNA packaging efficiency without affecting viral core particle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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