Thermo Fisher Scientific KCNJ5 Polyclonal Antibody
Thermo Fisher Scientific의 KCNJ5 Polyclonal Antibody는 인간 KCNJ5 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 IHC에 사용 가능하며, 높은 종간 서열 유사성(91%)을 보입니다. 연구용으로 안정적이며 장기 보관 시 -20°C에서 유지됩니다.
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Thermo Fisher Scientific KCNJ5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the cytoplasmic domain of human KCNJ5 (GIRK4, Kir3.4, KATP-1) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide shares 91% identity with rat and mouse sequences.
- Specificity: KCNJ5.
Target Information
G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus regions.
Also known as GIRK, Kir3 potassium channels localize to soma, dendrites, and axons of neurons.
Liberated Gβγ subunits from G protein heterotrimers bind to and regulate Kir3 channel activity.
Gβ3- and Gβ4-containing dimers increase K+ current, while Gβ5-containing dimers inhibit it.
Kir3 activity is also inhibited by tyrosine phosphorylation.
Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which phosphorylates Kir3 tyrosine residues, inactivating the channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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