Thermo Fisher Scientific ITGA2 Monoclonal Antibody (31H4)
인간 Integrin alpha 2(CD49b)를 인식하는 마우스 단클론 항체. Western blot, Flow cytometry, ELISA, IP 등 다양한 응용 가능. Protein G 정제, 1 mg/mL 농도 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:25–1:50 |
| ELISA | 10 µg/mL |
| Immunoprecipitation (IP) | 25–50 µg/mL |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 31H4 |
| Immunogen | Purified human beta 1 preparation from HT1080 fibrosarcoma cell extract (target: CD49b / Integrin alpha 2, UniProt ID: P17301-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_779707 |
Product Specific Information
MA1-26714 detects Integrin alpha 2 from human samples.
Target Information
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family.
It is a 150 kDa glycoprotein that complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (Integrin α2β1, or GPIa/IIa).
VLA-2 acts as an extracellular receptor for laminin, collagen, and fibronectin, activating intracellular signaling upon ligand binding.
CD49b plays roles in VEGF-induced angiogenesis, cell adhesion, and lymphocyte activation.
It is expressed on NK cells, NK-T cells, monocytes, platelets, epithelial cells, and subsets of T and B cells, including CD4+ Tr1 regulatory T cells co-expressing LAG-3.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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