Thermo Fisher Scientific ATP6V1B1 Polyclonal Antibody
Thermo Fisher Scientific의 ATP6V1B1 폴리클로날 항체는 인간, 마우스, 랫트에 반응하며 Western blot과 IHC(파라핀 절편)에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로, V-ATPase B1 단백질을 표적합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 426–471 of Human V-ATPase B1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719308 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Vacuolar-type H⁺-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles.
It pumps protons against an electrochemical gradient, while F-ATPases reverse this process to synthesize ATP.
V-ATPase consists of a peripheral V1 domain (ATP hydrolysis) and an integral V0 domain (proton translocation).
The V1 domain comprises nine subunits (A–H), and the V0 domain includes five subunits (a, d, c, c′, and c″).
The V-ATPase V1 B subunit has two isoforms:
- B1 isoform: functions in proton secretion in the inner ear, maintaining endolymph pH and normal auditory function.
- B2 isoform: expressed in kidney and osteoclasts.
Mutations in the human V-ATPase B1 gene (chromosome 2cen-q13) cause distal renal tubular acidosis with sensorineural deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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