Thermo Fisher Scientific PSME1 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1:1,000

Publications

• [References not provided]

Product Specifications

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus, while others are degraded via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine (~2.5 MDa) consisting of a 20S proteolytic core complex crowned by 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and play a key role in unfolding and translocating targets into the 20S lumen.
Defects in the ubiquitin-proteasome pathway are linked to genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.