Thermo Fisher Scientific Acetyl-p53 (Lys379) Polyclonal Antibody
p53 단백질의 Lys379 아세틸화 형태를 인식하는 폴리클로날 항체. 인간 및 생쥐 시료에 반응하며, WB, IHC, ICC, ChIP 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피 정제 제품으로, 액상 형태로 제공되며 -20°C에서 보관.
- 카탈로그번호
- PA517287
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Acetyl-p53 (Lys379) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| ChIP assay (ChIP) | 2 µL/10^6 cells | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic acetylated peptide corresponding to residues surrounding Lys379 of mouse p53 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 163 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10983350 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 regulates transcription of genes such as p21waf1, influencing G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.
Phosphorylation at Ser15 is critical for activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells and acts as an anticancer agent. It is also linked to aging, oxidative stress, and cognitive function. Mutations in TP53 often lead to loss of tumor-suppressor activity and are associated with various human cancers, including Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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