Thermo Fisher Scientific RAB21 Monoclonal Antibody (OTI5B12), TrueMAB
RAB21 단백질을 표적하는 Mouse IgG2b 단일클론 항체로, Western Blot 및 IHC(P) 검증 완료. 인간 반응성, 비결합형 동결건조 형태. 고순도 친화 크로마토그래피 정제 및 안정적인 PBS 버퍼 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B12 |
| Immunogen | Full length human recombinant protein of human RAB21 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RAB21 is a member of the Ras superfamily of small GTP-binding proteins involved in intracellular vesicular trafficking.
In non-polarized Caco-2 cells, RAB21 shows ER-like localization, while in polarized cells it localizes to apical vesicles.
RAB21 associates with integrin subunits and regulates receptor entry via RAB5/RAB21 endosomes.
The GTPase-activating protein p120RasGAP controls cell motility by influencing integrin recycling through competition with RAB21 for overlapping binding sites on the alpha-tail of endocytosed integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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